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Intended Learning Outcomes
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Select biological process conditions and configurations
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Use process modeling to analyze bioreactor performance
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Optimize bioprocess engineering technology
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Develop skills and insights to effectively perform research and
development of biological processes
Course Information
Course
coordinator: Prof. R Shanthini (accessible at 071-5326835 and at
rshanthini@pdn.ac.lk)
Evaluation
panel: Ms. SMWTPK Ariyarathne; Dr. C.S. Kalpage (Moderator)
Course credits: 3 GPA credits
Pre-requisites:
CP504
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Content
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Time allocated (in clock hours)
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Lecture
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Tutorial
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Project
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Assign.
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Biological systems for the production of
commercial goods and services: foods, drugs, chemicals, fuels, equipment,
diagnostics, and waste treatment.
Properties of microbial, plant and animal
cells, and of enzymes used in bioprocess applications.
Elementary aspects of molecular biology,
biochemistry, and microbiology.
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04
01
01
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30
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Enzyme kinetics and associated reactor
design.
Cellular kinetics and associated reactor
design.
Sterilization. Downstream processing.
Biochemical and biological constraints on
mass transfer, heat transfer, mixing and rheology.
Control of bioreactors.
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04
04
05
03
02
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02
02
02
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TOTAL (equivalent hours)
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24
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06
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15
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Note: Assign. stands for Assignment
Suggested Reference Texts
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Lee JM, 1992, Biochemical Engineering, New Jersey:
Prentice-Hall
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Shuler ML and Kargi F, 2005, Bioprocess Engineering - Basic
Concepts, Second Edition, New Delhi:
Prentice-Hall of India
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Aiba S, Humphrey AE and Millis NF, 1973, Biochemical Engineering, Second Edition, New York & London:
Academic Press
Assessment Scheme
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Assessment
method
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Percentage marks
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Continuous assessments
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25
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Assignments
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25
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Mid-semester examination
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25
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End-of-semester examination
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50
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Timeline for Lectures (subjected to fine-tuning)
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Week
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Cumulative hours
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Date
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Content
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1
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Lecture hr
01
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16 Sept
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Introduction to biological process
engineering (ppt)
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Lecture hr 02
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Overview of biological basics for engineers
(ppt, handout)
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2
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Lecture hr 03
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23 Sept
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Enzyme kinetics and associated reactor design:
Introduction to enzymes, enzyme catalyzed reactions and simple enzyme
kinetics (ppt, handout)
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Lecture hr 04
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Enzyme kinetics and associated reactor
design: Determination of the kinetic parameters of enzyme-induced reactions
(ppt)
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3
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Lecture hr
05
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30 Sept
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Enzyme kinetics and associated reactor design:
Immobilized enzymes (ppt)
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Lecture
hr 06
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Enzyme kinetics and associated reactor
design: Enzyme reactor design (ppt)
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4
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Lecture hr
07
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07 Oct
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Cellular kinetics and associated reactor
design: Reactor design for cell growth (ppt)
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Lecture
hr 08
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Cellular kinetics and associated reactor
design: Modelling cell growth (ppt)
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5
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Lecture hr 09
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14 Oct
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Field visit in CP503 (alternative hour should be provided
for advanced topics in enzyme kinetics
and cellular kinetics and associated reactor design)
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Lecture hr
10
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Field visit in CP503 (alternative hour should be provided
for advanced topics in enzyme kinetics
and cellular kinetics and associated reactor design)
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6
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Lecture hr
11
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21 Oct
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Tutorial
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Lecture
hr 12
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Tutorial
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7
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Lecture hr
13
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28 Oct
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Tutorial
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Lecture
hr 14
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Tutorial
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8
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04 Nov
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Mid semester Examination (Sample problems can be found at
http://www.che.ncsu.edu/haughlab/bioche_probs.html)
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continued….
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9
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Lecture hr
15
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11 Nov
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No lecture class
held
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Lecture
hr 16
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No lecture class
held
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10
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Lecture hr
17
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18 Nov
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Sterilization (ppt)
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Lecture
hr 18
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continued….
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11
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Lecture hr
19
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25 Nov
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continued….
(ppt and lecture notes handed
over)
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Lecture
hr 20
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continued….
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12
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Lecture hr
21
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02 Dec
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Presentation by students on biological
systems for the production of commercial goods and services, and other
related studies in bioprocess engineering
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Lecture
hr 22
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continued…
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13
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Lecture hr
23
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09 Dec
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Downstream processing (lecture notes handed
over)
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Lecture
hr 24
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continued….
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14
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Lecture hr
25
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16 Dec
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Biochemical and biological constraints on
mass transfer, heat transfer, aeration, agitation, scale-up and rheology (ppt and lecture notes
handed over)
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Lecture
hr 26
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continued…
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15
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Lecture hr
27
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23 Dec
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continued…
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Lecture
hr 28
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continued…
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Past Examination Papers
Assignment related
Information
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E number
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Student name
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Assignment
presentation/
submission
date (time)
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Assignment
type / topic
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E/04/146
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Karunathilake TDUS
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02 Dec (12 noon)
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report
not submitted
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E/06/022
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Ariyaratna IL
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02 Dec (12 noon)
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E/06/026
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Asela APP
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02 Dec (12 noon)
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E/06/035
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Bandara WMSC
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02 Dec (12 noon)
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E/06/084
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Harischandra YG
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02 Dec (12 noon)
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E/07/028
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Ariyawansha KRHU
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02 Dec (12 noon)
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E/07/047
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Chandrasekara RPMU
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02 Dec (12 noon)
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E/07/066
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Dharmasiri GAN
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02 Dec (12 noon)
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report
not submitted
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E/07/142
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Izzadheen BAA
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02 Dec (12 noon)
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E/07/143
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Jameel SHJA
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02 Dec (10-12)
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E/07/149
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Jayasinghe AS
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02 Dec (12 noon)
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E/07/183
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Kodithuwakku SI
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02 Dec (12 noon)
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E/07/234
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Narampanawa EMSN
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02 Dec (10-12)
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report
not submitted
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E/07/288
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Rathnayake RMGD
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02 Dec (12 noon)
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E/07/299
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Rishadh AM
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02 Dec (10-12)
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E/07/316
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Sameera HJN
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02 Dec (12 noon)
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E/07/343
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Shashinkamali PKGT
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02 Dec (10-12)
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E/07/415
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Sandaruwan SMJ
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02 Dec (12 noon)
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